Given the varied outcomes of these and other studies, as well as the apparent paucity of data on school-aged children (SAC) who present with the highest risk of infection/re-infection to schistosomiasis, we sought in this cross-sectional work, to assess the associations between SNPs in the IL-13 gene promoter region (namely, IL13-1055C/T, IL13-591A/G and IL13-1258A/G) and schistosomiasis infection levels among selected schoolchildren in four S. haematobium-endemic communities. The gene discussed is IL13; the disease is infection.