Immunohistochemical analysis revealed substantially higher levels of MYH11 present in the media of normal aortas, as well as in lenvatinib-treated PPE-AAA; however, it was completely absent in regular PPE-induced AAAs (Figure 1, C–E; and Supplemental Figure 2, with quantification in Figure 2A). This evidence concerns the gene MYH11 and achalasia-alacrima syndrome.