In addition to more closely mimicking the advanced human AAA phenotype, LDLR–/– minipigs developed more enlarged AAAs compared with their WT normo-cholesterolemic companions (82 ± 24% vs. 50 ± 13% diameter increase; P < 0.05) 28 days after PPE induction. Here, LDLR is linked to achalasia-alacrima syndrome.