EGFR and lung adenocarcinoma: The latest national LC guideline from 2014 only mentions epidermal growth factor receptor (EGFR) testing and guided therapy for lung adenocarcinoma as optional, without mention of programmed death ligand 1 testing or specific therapy.14 A Colombian consensus on advanced LC addressed PDL1, EGFR, ALK, and ROS1. 15 Molecular testing for cancer of unknown primary (CUP) is not covered in any national guideline.