We found the tumor infiltrating MAIT cells expressed genes related with activation and exhaustion, such as pro‐inflammatory cytokine TNFα, CTLA‐4, HAVCR2, Granzyme A, and Granzyme B, suggesting their polyfunctionality in response to bacteria and/or metabolites present in the tumor microenvironment in CRC (Figure 3B). Here, TNF is linked to colorectal carcinoma.