In comparison with adjacent and precancerous tissues, we found a significant reduction of CD40+, CD27+, KLRB1+, and CCL5+ B cells (clusters 4, 9, 1, and 3, respectively) and MZB1+, DUSP1+, and CCL3+ plasma cells (clusters 5, 7, and 8) in tumor tissues (Figure 6B). The gene discussed is CD40; the disease is neoplasm.