In addition, we performed WES on tumor tissues of seven patients that were accessible, and identified the cohort harbored most of the canonical mutations detected in CRC, such as PIK3CA, MLH1, ROS1, KRAS, APC, TP53, PIK3CG, JMJD1C, ASXL1, CHD4, and JAK2 mutations (Figure 1C). This evidence concerns the gene MLH1 and neoplasm.