To further explore the underlying molecular mechanisms that shape the tumor immune microenvironment, we performed single‐cell assay for transposase accessible chromatin using sequencing (scATAC‐seq) to profile the epigenetic landscape on 6526 CRC cells sampled from the same adjacent and tumor tissues for above scRNA‐seq from six patients (Pt7, Pt9, Pt12, Pt14, Pt17, and Pt20) (Figures 1A and 2). This evidence concerns the gene ZNF80 and neoplasm.