The lung metastasis model revealed that the stable overexpression of MCM10 in both KYSE30 and KYSE150 cells can significantly facilitate colonization of the lung and increases the number of lung metastases, whereas the knockdown of MCM10 in both ESCC cells substantially inhibited these effects (Figures 4F and 4G). The gene discussed is MCM10; the disease is esophageal squamous cell carcinoma.