Also, we found that MCM10 presented a high dependence degree in two different esophagus cancer cell line TE4 and TE6 based on the loss‐of‐function screens data of CRISPR/Cas9 technology31 (Figure 3E), suggesting the MCM10 is essential for ESCC cells proliferation. Here, MCM10 is linked to esophageal squamous cell carcinoma.