Overall, METTL3‐mediated m6A modification contributes to the upregulation of PCAT6 in an IGF2BP2‐dependent manner and the PCAT6/IGF2BP2/IGF1R complex further stabilizes IGF1R mRNA to activate downstream pathways, which promotes BM and tumor growth in PCa (Figure 8N). Here, PCAT6 is linked to posterior cortical atrophy.