RIP analysis indicated that PCAT6 was significantly enriched in IGF2BP2 protein instead of other m6A readers (Figure 7H and Figure S7h) and METTL3 knockdown dramatically decreased PCAT6 enrichment in IGF2BP2 protein (Figure 7H), indicating that METTL3‐induced m6A modification regulated the recognition and binding of methylated PCAT6 by IGF2BP2. Furthermore, the expression and half‐life of PCAT6 were strongly reduced upon IGF2BP2 inhibition in PCa cells (Figure 7I and Figure S7i), which was similar to the results of METTL3 inhibition. Here, METTL3 is linked to posterior cortical atrophy.