In this study, we have now identified a definitive mechanism for neutrophil chemotaxis; tumor tissues can produce more CXCL6/CXCL8 when compared to non‐tumor tissues, which attracts neutrophil migration via CXCL6/CXCL8‐CXCR1 interactions, suggesting that CXCL6/CXCL8‐CXCR1 axis plays important roles in the migration of neutrophils in GC. Here, CXCL8 is linked to neoplasm.