Of them, the ligand–receptor interactions between anti‐inflammatory macrophages (CCL20lo/CD163hi macrophages, APOE+ macrophages, and T1‐IFN activating macrophages), neutrophils, and DCs are most significant, followed by the interactions between anti‐inflammatory macrophages and tumor cells/endothelial both in tumor and normal tissues (Figures 6A–6C). This evidence concerns the gene APOE and neoplasm.