Compared with adenocarcinoma, squamous cell carcinoma showed strong communications with endothelial by the MIF/TNFRSF10D, EGFR/GRN, EGFR/HBEGF, and EPHB2/EFNB2 interactions (Figures 6B and 6D). The gene discussed is EFNB2; the disease is adenocarcinoma.