For CD8+ T cells, although the cytotoxic molecules (GZMA, GZMB, NKG7, and PRF1) were highly expressed, a fraction of CD8+ T cells showed positive with exhaustion biomarkers (CTLA4, PDCD‐1, and TIGIT), indicating their tumor‐cytotoxic activity was constrained. The gene discussed is GZMA; the disease is neoplasm.