Taken together, these findings reveal that the lack of miR‐146a/b in mice leads to increased numbers of neutrophils, DCs, and T cells in the airways with concomitantly enhanced expression of the neutrophil chemoattractant Cxcl1, as well as neutrophil markers S100a8 and S100a9 in the lung tissue during RV‐A1b infection. This evidence concerns the gene S100A8 and infection.