To investigate the mechanism of lipid metabolism changes induced by melatonin in PCa, lipid‐related genes were identified in the top 30 DEGs based on the RNA sequencing results; three genes (DHRSX,27 HNF4A,28 and CES129) were upregulated, and six genes (SLC7A10,30 IGFBP1,31 ALDH1A2,32 ACSBG2,33 ZIC1,34 and SLC38A435) were downregulated in the C4‐2 cells treated with MLT compared with the control cells (Figure 2A). Here, DHRSX is linked to posterior cortical atrophy.