In this study, we found that high expression of clathrin heavy chain (CLTC) was an independent prognostic factor for tumor‐free survival (HzR, 3.049; 95% CI, 1.476–6.301) and overall survival (HzR, 2.469; 95% CI, 1.005–6.067) of patients with osteosarcoma. The gene discussed is CLTC; the disease is neoplasm.