Based on the PubMed data, 10 out of the 22 up‐regulated genes (VCAN, TPM4, GJA1, POSTN, THBS2, LOX, SERPINE2, TIMP1, COL1A1, and COL1A2) have been reported to be associated with osteosarcoma. The gene discussed is VCAN; the disease is osteosarcoma.