Hypergeometric testing using the reference dataset of Xie's study43 showed a clear overrepresentation of SRF‐targeting network members in megakaryoblastic leukemia‐1/2 (MKL1/2) regulated SRF‐dependent genes (p‐value = 2.7E‐03), but not in ETS‐domain protein 4 (ELF4) regulated SRF‐dependent genes (Figure 4C). Here, SRF is linked to adult acute megakaryoblastic leukemia.