VEGF or Dll4‐Notch signaling upregulations to play decisive roles in tumor formation and metastasis, probably through VEGF or Dll4‐mediated formation of TEC subgroups (i.e., tip‐like, transition, and stalk‐like cells) (Figure 1), as evidenced by scRNA‐seq profiles and tip TEC signature genes are well related with patient survival.10 The gene discussed is DLL4; the disease is neoplasm.