Proteins in plasma (including TFPI, antithrombin, and fibrinogen) have important influences on TG, tested by protocols recommended for bleeding disorder assessment,11 without thrombomodulin and activated protein C.18The important effects that plasma proteins have on TG likely underlie the strong associations that we found between PRP and PPP TG findings, for both PFD and control subjects. The gene discussed is TFPI; the disease is hemorrhagic disease.