To further confirm that downregulation of sericin 1 gene expression affects the cellular immune response, the DEGs associated with the Epstein–Barr virus infection and hepatitis C pathways were analyzed; these included cytochrome c (Cytc), inhibitor of nuclear factor kappa‐B kinase (IKK), RAC serine/threonine protein kinase (RAC‐PK), thioredoxin domain‐containing protein (TXNDC), calreticulin, scavenger receptor class B member 4 (SCARB4), and lysosome membrane protein 2 (SCARB1). This evidence concerns the gene CALR and hepatitis C virus infection.