Our observation that several tumor characteristics were statistically significantly predictive of overweight and obese BMI following LR tests indicates that the somewhat paradoxical relationship between BMI and tumor aggressiveness might be due to varying roles of estrogen metabolism, adiponectin, insulin-like growth factors, chronic inflammation, and/or delayed detection in obesity-related breast carcinogenesis [29, 37–39]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.