From the results of the univariate analysis, the following factors were introduced to the multivariable model (entered method): diabetes, BMI, CURB-65, fever, respiratory rate (RR), heart rate (HR), arthromyalgia, mottling, pH, PaO2/FiO2 ratio at admission, WBC, Lymphocytes, Neutrophiles, CRP, D-dimer, prothrombin time (PT), troponin at admission, CPK, LDH, AST, ALT, CT-chest extension > 50%, ARDS, septic shock, acute kidney injury (AKI) and mechanical ventilation (MV). This evidence concerns the gene CRP and acute kidney injury.