CD274 and non-small cell lung carcinoma: Also, ERK mediates PD-L1 expression in NSCLC (non small cell lung carcinoma) cells with ROS1 fusion: Liu and coworker showed that both ERK phosphorylation and PD-L1 expression were down-regulated after treating HCC78 cells with PD0325901 or U0126 (Liu et al. 2020).