CD274 and non-small cell lung carcinoma: In concordance, Qian and colleagues showed a decreased PD-L1 mRNA expression after ERK1/2 inhibition in bladder cancer cells (Qian et al. 2008), and Liu and coworkers confirmed a downregulation of PD-L1 expression and ERK phosphorylation in NSCLC cells after PD0325901 or U0126 treatment (Liu et al. 2020).