The gene BMPR2 is named in several studies as an important factor in the progression of PAH in humans and also in the monocrotaline rat model of PAH (Garcia-Rivas et al. 2017; Tuder et al. 2013; Lane et al. 2000; Machado et al. 2015; Cheng et al. 2017). This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.