Cancer development and progression was seen to be affected by Tnfrsf1a, Adrbk2, Pld4, Gnat1 and Samsn1 in other studies (Greco et al. 2015; Gao et al. 2017; Sang et al. 2016; Jiang et al. 2017; Kanda et al. 2016; Noll et al. 2014). Here, PLD4 is linked to cancer.