2014), and its high expression level is positively associated with the degree of edoema (Badaut et al. 2014). Thus, AQP-4 inhibition can effectively treat cytotoxic brain swelling in early cerebral infarction (He and Lu 2015). Although pre-treatment with SHJKSmex did not significantly suppress AQP-4 expression, the values showed a decreasing tendency (Figure 5(C)). Here, AQP4 is linked to brain infarction.