AGT and rheumatoid arthritis: 2018). As a result, the expression of IL-1β, IL-17, transforming growth factor-β, platelet-derived growth factor, placental growth factor, angiopoietin (Ang) I, and Ang II were reduced in the synovium of RA rats (He et al. 2018). Zhang et al. (2016) reported that WTD induced thermogenesis by modulating the peroxisome proliferator-activated receptor γ-pathway, which can alleviate RA.