PNPLA3 and liver disorder: Despite the exact biological mechanism of the PNPLA3‐HSD17B13 interaction is not clear, these results suggest that targeting HSD17B13 may reduce the risk of liver disease in those with a higher risk conferred by PNPLA3 p.I148M, and that the HSD17B13 protective potential may be stronger in individuals with a high BMI.