NTSR1 and retinitis pigmentosa 1: Importantly, investigations of lead compound MOA, led to the discovery that NTR/Mtz-mediated rod cell death appears to proceed through alternative cell death pathways (Figure 8) recently linked to photoreceptor degeneration in mammalian models of RP (Arango-Gonzalez et al., 2014; Paquet-Durand et al., 2007; Power et al., 2020; Sancho-Pelluz et al., 2008; Tolone et al., 2019).