As PARP-dependent cell death pathways are implicated in the etiology of Parkinson’s disease (Kam et al., 2018), RP (Power et al., 2020), and other neurodegenerative disorders (Fan et al., 2017; Fatokun et al., 2014), NTR/Mtz-mediated cell ablation may serve as an inducible and titratable methodology for modeling neurodegenerative disease. Here, PARP1 is linked to neurodegenerative disease.