High cost versus MDISome are complex to useRisk of insulin errors due to pump failure, insulin infusion set blockage, infusion site problems, insulin stability issues, user error, or a combination of theseRisk of serious complications (e.g. ketosis and DKA) if infusion set becomes dislodged or occluded; pump site becomes infectedPotential for user issues with disliking pump, psychological impact (e.g. anxiety or depression). This evidence concerns the gene INS and depressive disorder.