The recently published Phe2561Tyr variant in the VWF gene is a gain-of-function variant and has been proven to be an independent risk factor for early and repeated myocardial infarction in women.15, –17 Structural and functional analysis indicate that the VWF-V is more susceptible to shear stress induced elongation, which is mandatory for its proper function and therefore conveys a prothrombotic state in carriers of this genetic variant.17,18. This evidence concerns the gene VWF and myocardial infarction.