VWF and myocardial infarction: The recently published Phe2561Tyr variant in the von Willebrand factor (VWF) gene is a gain-of-function variant and has been proven to be an independent risk factor for early and repeated myocardial infarction in women.15, , –18 We therefore assessed clinical characteristics and 3 known prothrombotic mutations in factor V, prothrombin (factor II), and von Willebrand factor in a cohort of anticoagulated patients with LA thrombus (LAT-group) and a control group without LA thrombus.