RUNX3 and colorectal carcinoma: [] introduced the prevailing method used to identify CIMP in CRC, which is based on the methylation status of five genes: calcium voltage‐gated channel subunit alpha‐1 G (CACNA1G), insulin‐like growth factor 2 (IGF2), Neurogenin 1 (NEUROG1), runt‐related transcription factor 3 (RUNX3) and suppressor of cytokine signaling 1 (SOCS1).