Intriguingly, several of the predicted TCF4 interactors have been linked to neurodevelopmental disorders featuring corpus callosum abnormalities (Pringsheim et al., 2019; Filatova et al., 2019; Tzeng et al., 2014; Snijders Blok et al., 2019; Hempel et al., 2016), suggesting a pathophysiological relevance of the proposed TCF4 TF network. This evidence concerns the gene TCF4 and neurodevelopmental disorder.