Yan et al. showed that PP1-mediated inhibition of the Src kinase reduced fibrosis in either the presence or absence of transforming growth factor-β (TGF-β) stimulation in vitro and attenuated renal interstitial fibrosis after the development of unilateral ureteral obstruction in vivo [43]. This evidence concerns the gene TGFB1 and Ureteral obstruction.