TNF and psoriasis: The immune-inflammatory profile of psoriasis was identified in this study. According to study findings, the type-1 profile of cytokines (TNF-α, IL-2, and INF-γ) was recognized as the leading inflammatory and INF-γ) was recognized as the leading inflammatory markers of psoriasis. The over-expression of VCAM-1, ICAM-1, was also observed on skin biopsies of diseased persons.