Given the essential roles TLR and NFKB-pathways play in sepsis as identified previously11,12 and through our in silico analysis, this work aimed to explore the transcriptomic signature and the clinical utility of MYD88, IRAK1, NFKB, and IL6 in a sample of neonatal sepsis and to correlate the gene signature with the clinic-laboratory data. Here, MYD88 is linked to Neonatal sepsis.