TLR7 and Autoimmunity: Similarly, PBM treatments also downregulated the expression of 15 genes (Ltb, Ccl22, Ccl20, Il17a, Ccr4, Ccr7, Il7, Crp, Il9, Lta, Ccl17, Ifng, Cxcl9, Il22, Kng1, Il23r, and Il5) and upregulated 3 genes (Cxcl5, Ccl8, and Tlr7) among the 84 genes in the inflammatory response and autoimmunity array (Fig. 5e, f, and Fig. S5d–f).