Notably, the expression of both RORα and BMAL1 is strongly repressed in MYCN-amplified (MNA) NB (cohort 1, Fig. 1; cohort 2, Supplementary Fig. 1a), and this correlates with poor overall (OS) and progression-free survival (PFS) in all patient cohorts (Fig. 1 and Supplementary Fig. 1). This evidence concerns the gene MYCN and neuroblastoma.