TNFRSF1A and dementia: We confirmed that, compared to those with high p-Tau181 levels and low predicted TNFR1 score, MCI participants with high p-Tau181 and predicted sTNFR1 scores (p = 0.038) or low p-Tau181 levels (p = 0.068) each had reduced likelihood of conversion to dementia (Fig. 4b).