To identify potential correlations between functionally-related CSF inflammatory proteins (after log-10 and Z-transformation; see “Methods” and Supplementary Tables 2 and 3), we performed dimension reduction using PCA21 on the 15 proteins we measured with previously measured levels of core AD biomarkers (Aβ42, t-Tau, p-Tau181, t-Tau/Aβ42), sTREM2, and progranulin. This evidence concerns the gene GRN and Alzheimer disease.