This murine model mechanistically showed NLRP3-regulated IL-18-induced eosinophil accumulation and degranulation, merged pancreatic ducts, pancreatic intraepithelial neoplasia 1 (PanIN1), PanIN2, PanIN3, and intraductal papillary mucinous neoplasm (IPMN). The gene discussed is NLRP3; the disease is pancreatic intraductal papillary-mucinous neoplasm.