Furthermore, analysis using the combination of anti-CD11b/anti-CD86 and anti-CD11b/anti-CD206 double immunofluorescence we observed that M1 macrophages are highly induced compared with M2 macrophages in the pancreas tissue sections of mice treated with cerulein plus AOM compared with mice treated with cerulein, AOM plus saline, or saline alone treated mice (Fig S2B–D). Here, ITGAM is linked to infectious otitis media.