The eosinophil granular protein EPX up-regulates TGF-β, KRAS, and MUC2, resulting in collagen and mucin accumulation, ADM, and formation of PanINs, IPMN, and MCN in the pancreas after cerulein-with-AOM treatment in mice. Here, MUC2 is linked to pancreatic intraductal papillary-mucinous neoplasm.