TP53 and neoplasm: KRAS oncogene expression in various settings with additional mutations, including deletion or inactivation of p53 or TGF-β signaling molecule SMAD4, is significant in tumor development and, in some instances, acquisition of metastatic properties (Aguirre et al, 2003; Tuveson & Hingorani, 2005; Bardeesy et al, 2006).