Similarly, a reduced immunoreactivity of anti–TGF-β (Fig 5Div–v), anti-MUC2 (Fig 5Eiv–v), anti-KRAS (Fig 5Fiv–v), anti-p53 (Fig 5Giv–v), mucin (Fig S6Biv–v), and collagen accumulation (Fig S6Civ–v) in the tissue sections of the anti–IL-18–pretreated and cerulein-with-AOM–treated mice was observed compared with the cerulein-with-AOM–treated mice without anti–IL-18. The gene discussed is TP53; the disease is infectious otitis media.