Eosinophils are the source of the profibrotic cytokine TGF-β and are involved via the signaling molecule SMAD4 in promoting pancreatic fibrosis that may lead to the development of characteristic features observed in PC (Thakur et al, 2016; Ahmed et al, 2017; Kandikattu et al, 2021a). The gene discussed is TGFB1; the disease is pachyonychia congenita.