Similarly, highly induced profibrotic proteins such as lumican (LUM), periostin (POSTIN), and fibroblast growth factor (FGF1) (Fig 2E) and highly induced PC-associated oncogenic proteins like SPRR1A and AKR1B8 (Fig 2F) were observed in mice treated with cerulein plus AOM compared to those treated with cerulein alone or saline. The gene discussed is SPRR1A; the disease is infectious otitis media.