FGF1 and infectious otitis media: Similarly, highly induced profibrotic proteins such as lumican (LUM), periostin (POSTIN), and fibroblast growth factor (FGF1) (Fig 2E) and highly induced PC-associated oncogenic proteins like SPRR1A and AKR1B8 (Fig 2F) were observed in mice treated with cerulein plus AOM compared to those treated with cerulein alone or saline.