IL18 and pachyonychia congenita: We show that both IL-18 gene deficiency and neutralized anti–IL-18 immunotherapy in mice down-regulate profibrotic and oncogenic proteins and pathological characteristic features, such as inhibition of acinar cell hypertrophy, ADM, and proinflammatory stroma, including PanIN1, PanIN2, and PanIN3 formation in a cerulein-with-AOM–induced inflammation-mediated murine model of PC.