The Western blot and immunohistochemical analyses on oncogene induction are consistent with the proteomic analysis that detected several other critical oncogenic proteins including ANXA4, LRP1, TAP1, Serpina3, NTAP1, KRAS, SerpinH1, AKR1B8, and SPRR1A in the presented murine model, all of which have been reported as lifetime risk factors for PC in humans. Here, SPRR1A is linked to pachyonychia congenita.