The primary cause of death was more likely to be attributed to diseases of the circulatory system (49.4% of deaths), and specifically HF (4.8%), in those with NT-proBNP >2000 pg/mL (Table S) compared with those with lower NP values (36.0% and 4.8%, respectively, p<0.001 for both). Here, NPPB is linked to cardiovascular disorder.