Since the initial discovery of MG53 in 2009 [4, 5, 45], rapid progress has been made in understanding the mechanistic actions of this protein in both the biology of tissue repair and in regulating metabolic syndromes. Several studies published from Xiao and colleagues [32, 46, 47] suggested MG53 might be a causative factor for diabetes (Table 1). Here, TRIM72 is linked to diabetes mellitus.