TGFB1 and neoplasm: However, not all types of malignancies exhibit the same immune microenvironment since it has been established that there are six immune-based subtypes of malignancies according to total lymphocytic infiltrate, immune cell fractions, immune gene expression signatures, neoantigen prediction, viral RNA expression and somatic DNA alterations (wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGFβ dominant) [58], reinforcing the idea that the molecular signature of each tumor exerts a specific influence on its environment.