On the other hand, NPTX2 was the best correlate of CSF Aβ1-42 (r = .58, adj.p < .0001), showed the greatest fold-change across all AD stages (0.34 to 0.55-fold, adj.p < .002), and was the only synaptic protein to show changes in pDS (0.47-fold, adj.p = .002). This evidence concerns the gene NPTX2 and Alzheimer disease.