The main tumor suppressors downregulated in AT are PCDH10 (log2FC − 4.76), a protocadherin whose promoter is methylated in diffuse large B-cell lymphomas [29] or PTPN13 (log FC: − 2.84) an inhibitor of FAS-induced apoptosis associated with aggressive breast cancer [30]. The gene discussed is PCDH11X; the disease is breast cancer.