After exclusion of patients with bone metastatic disease, both hypoalbuminemia and high CRP were associated with a negative bone turnover (CTX/Ocn: OR 10.5 for hypoalbuminemia and OR 7.6 for high CRP; CTX/PINP: OR 7.7 for high CRP; p ≤ 0.01) (Table 4). This evidence concerns the gene CRP and Hypoalbuminemia.