To identify determinants of negative bone remodeling balance in cancer patients, we performed a logistic regression analysis, which revealed hypoalbuminemia for the CTX/Ocn ratio (OR of 19.8, 95% CI 3.5–111, p < 0.01) and high CRP for the CTX/PINP ratio (OR of 5.29, 95% CI 1.6–17.5, p < 0.01) as main indicators of unbalanced bone turnover in the whole patient population. The gene discussed is CRP; the disease is cancer.