SPEG and Cognitive impairment: Striated Muscle Enriched Protein Kinase (SPEG) and UBE2L3 that may be structurally and functionally related to Ubiquitin Conjugating Enzyme E2 G1 (UBE2G1) were differentially methylated genes associated with cognitive impairment [40] and circulating UBE2G1 transcripts may have potential as biomarkers [41].