Univariate Cox regression analysis initially identified that among 97 MDGs, 6 MDGs (CBLN2, GSTM1, RBM47, SH3GL3, SLCO4C1, and TMEM220) were significantly correlated with OS of COAD patients (Table 1, P < 0.05). The gene discussed is TMEM220; the disease is colon adenocarcinoma.