Due to excessive presence of IFN-γ and GM-CSF in the serum of a COVID-19 patient [27], these can activate JAK/STAT pathway and lead to the upregulation of several interferon stimulated genes [52] which can elevate the amount of cytokines having the ability to attack self cells and induce inflammation in RA. The gene discussed is SOAT1; the disease is rheumatoid arthritis.