To assess ISG expression in pDC transcriptomes, we examined ISG expression in several ways: first, we measured expression of a 19-gene ISG signature panel representative of Type I IFN signaling we have described previously as being upregulated in RMs after SIVmac239 infection [25,27] and sensitive to inhibition by in vivo antagonism of the IFNAR [76]. The gene discussed is IFNAR1; the disease is infection.