During the preparation of these manuscript, a study from Bojkova D et al, 2020 was published suggesting a possible role of SPINT1, SPINT2 and SERPINA1 in viral infection by observing the down-regulation of their protein levels in infected cells and also by evaluating the effect of Aprotinin a non-specific SP inhibitor on viral load [9]. This evidence concerns the gene SPINT2 and viral infectious disease.