CD4 and neoplasm: Recognition of these MHC-peptide complexes by CD4+ or CD8+ T-cells initializes an anti-tumor immune response and leads to an influx of T cells into the tumor microenvironment [1,7,8], Longer NORFS, consisting of at least 50 aminoacids, so called super NORFS (SNORFS), have a higher chance to be recognized as a neo-antigens [9].