An ARC Kiss1 loss-of-function mouse model, induced by AAV1-DIO-GFP:tetanus toxin (TeTx) viral stereotaxic injection into adult Kiss1-Cre female mice (Table 1), demonstrated an increase in body weight and obesity due to dysregulated feeding behavior (25). The gene discussed is ARC; the disease is obesity due to melanocortin 4 receptor deficiency.