CCKBR and neoplasm: As a tumor suppressor gene, it inhibits cell proliferation and induces apoptosis by suppressing the action of multiple proteins as Bcl-2 (Zheng et al., 2011; Wang, 2020), ROCK1 (Li et al., 2013), CCKBR (Zhang et al., 2014 a), and DNMT1 (Lombard et al., 2015).