This can be referred to its role in the initiation and progression of NSCLC by acting on different target genes that inhibit cell migration and invasion as SMAD2 (Wang et al., 2013), DNMT1 (Lombard et al., 2015), MMP7 (Sakamoto et al., 2014), MET (Zhang et al., 2014b), and WNT1 (Yan et al., 2014). This evidence concerns the gene SMAD2 and non-small cell lung carcinoma.