Initially, the lymphocytes were most likely activated and induced to come to tumor microenvironment, as can be seen from Figure 1 that few lymphocytes located far from tumor cells which showed nuclear expression of NFATc1 suggesting that NFATc1 is essential for T and B lymphocytes activation, homeostasis and differentiation (Vaeth and Feske, 2018). Here, NFATC1 is linked to neoplasm.