Known as an essential transcription factor in many physiologic systems comprising immune cells (Vaeth and Feske, 2018), including in regulation of PD-1 activation (Oestreich et al., 2008), nuclear factor of activated T cell (NFATc1) has roles in tumor microenvironment (Li et al., 2018; Gholami et al., 2017). The gene discussed is NFATC1; the disease is neoplasm.