Prior studies have revealed the CCA-1.1 parent compound PGV-1 exerted an anti-migratory effect and lowered the MMP-9 and Rac-1 expressions in TNBC 4T1cells; this phenomenon was also presented in HER2+ breast cancer cells (Meiyanto et al., 2021, 2019). This evidence concerns the gene RAC1 and breast carcinoma.