On the other hand, the expression of MMP-2 tended to be lower in breast carcinoma against that in normal tissues, with a fold change of -3.514 (Figure 6B), as suggested by in vitro studies, while MMP-2 and MMP-9 were highly expressed in breast cancer tissues and associated with worsening prognosis (Li et al., 2017). This evidence concerns the gene MMP2 and breast cancer.